Advocating for Californians Impacted by PANS/PANDAS
PANS/PANDAS Research & Medical Resources
Scientific research continues to advance our understanding of PANS/PANDAS, including the roles of immune dysfunction, neuroinflammation, and infections in these complex conditions.
Explore published studies, clinical research, treatment guidelines, and resources from leading medical institutions dedicated to improving recognition, diagnosis, and care for children and young adults affected by PANS/PANDAS.
Research & Medical Guidance
National Institutes of Health (NIH)
PANS/PANDAS Research Overview
The National Institutes of Health supports research into PANS/PANDAS, investigating the potential roles of infections, immune dysfunction, and neuroinflammation in these complex conditions. Ongoing research aims to improve understanding, diagnosis, and treatment for affected children.
Read the NIH Research Overview
National Institute of Mental Health (NIMH)
PANS and PANDAS: Questions and Answers
The National Institute of Mental Health provides information on the symptoms, possible causes, diagnosis, and treatment of PANS/PANDAS, helping families and healthcare professionals better understand these complex conditions.
World Health Organization (WHO)
International Classification of Diseases (ICD-11)
The World Health Organization maintains the ICD-11, an international classification system used to document diseases and health conditions. It provides a framework for standardized medical coding and health reporting worldwide.
Explore the WHO ICD-11 Classification
Tufts Medicine
PANS and PANDAS in Children: Symptoms, Causes & Treatment
Tufts Medicine highlights the importance of recognizing PANS/PANDAS, understanding their complex symptoms, and providing appropriate medical evaluation and individualized treatment for affected children.
Published Scientific Research & Clinical Studies
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1. Yale University | 2021
Antibodies From Children With PANDAS Bind Specifically to Striatal Cholinergic Interneurons and Alter Their Activity
Researchers identified antibodies in samples from children with PANDAS that interacted with specific brain cells involved in movement and behavior. The findings offer evidence of a possible immune mechanism that warrants further investigation.
2. JAMA Psychiatry | 2017
Association of Streptococcal Throat Infection With Mental Disorders: Testing Key Aspects of the PANDAS Hypothesis in a Nationwide Study
This large Danish population study examined more than one million children and found an association between streptococcal throat infections and increased risk of certain psychiatric disorders, including OCD and tic disorders. The findings do not establish causation.
Read the nationwide study on PubMed
3. Yale University and NIMH | 2016
Randomized, Controlled Trial of Intravenous Immunoglobulin for Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections
This clinical trial investigated IVIG treatment in children with PANDAS. Although some participants improved, the blinded comparison did not demonstrate a statistically significant benefit over placebo, highlighting the need for further controlled research.
PubMed
4. Clinical Research | 2021
Evaluation of Intravenous Immunoglobulin in Pediatric Acute-Onset Neuropsychiatric Syndrome
This study examined symptom changes following IVIG treatment in children with PANS. It contributes to ongoing treatment research, although its uncontrolled design limits conclusions about effectiveness.
Read the full published study.
5. Epidemiological Research | 2005
Association Between Streptococcal Infection and Obsessive-Compulsive Disorder, Tourette's Syndrome, and Tic Disorder
This case-control study investigated whether previous streptococcal infections were associated with the development of OCD and tic disorders. Researchers reported associations supporting further investigation of infection-related neuropsychiatric symptoms.
Read the epidemiological study.
PubMed
6. Stanford University | 2017
Effect of Early and Prophylactic Nonsteroidal Anti-Inflammatory Drugs on Flare Duration in Pediatric Acute-Onset Neuropsychiatric Syndrome
Stanford researchers examined whether anti-inflammatory medication use was associated with shorter PANS symptom flares. This observational study identified a potential treatment association that requires confirmation through controlled clinical trials.
Explore Additional PANS/PANDAS Research
Stanford University | PANS Research Publications
Explore scientific publications and clinical research associated with Stanford's PANS program, including investigations into symptoms, immune mechanisms, and treatment approaches.
Explore Stanford PANS Research Publications
PANDAS Physicians Network (PPN) | Research Library
Access a collection of published scientific studies and medical literature related to PANS/PANDAS, including research on diagnosis, immune dysfunction, and treatment.
Explore the PPN Research Library